2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-18056
    PF-915275 857290-04-1 99.74%
    PF-915275 is a potent, selective and orally active human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor with a Ki of 2.3 nM and an EC50 of 15 nM (in HEK293 cells). The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC50 of 20 and 100 nM, respectively.
    PF-915275
  • HY-19702
    PKR activator 3 1628428-01-2 99.82%
    PKR activator 3 is a pyruvate kinase isoform PKR activator extracted from patent WO2014139144A1, compound 160. PKR activator 3 can be used for the research of PKR function related diseases, including cancer, diabetes, obesity, autoimmune disorders, and benign prostatic hyperplasia.
    PKR activator 3
  • HY-20696
    Tetrahydro-β-carboline 16502-01-5 99.40%
    Tetrahydro-β-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive serotonin reuptake inhibitor with an Ki value of 6.1 µM.
    Tetrahydro-β-carboline
  • HY-32337
    Tacalcitol 57333-96-7 99.71%
    Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) can promote normal bone growth by regulating calcium ions. Tacalcitol inhibits cancer cell proliferation and migration. Tacalcitol can be used in the research of inflammation, cancer, and skin diseases.
    Tacalcitol
  • HY-33893
    Indole-3-methanamine 22259-53-6
    Indole-3-methanamine is a potential biomarker for the consumption of these foods such as barley, cereals, and cereal product.
    Indole-3-methanamine
  • HY-66047
    2,4-Dihydroxypyrimidine-5-carboxylic Acid 23945-44-0
    2,4-Dihydroxypyrimidine-5-carboxylic Acid is an endogenous metabolite.
    2,4-Dihydroxypyrimidine-5-carboxylic Acid
  • HY-76383
    LR-90 245075-84-7 99.59%
    LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes. LR-90 is also used in the research of diabetic animal model.
    LR-90
  • HY-B0051
    Carbazeran 70724-25-3 98.31%
    Carbazeran, a potent phosphodiesterase inhibitor, is aldehyde oxidase substrate. Carbazeran can be used for the research of metabolic disease.
    Carbazeran
  • HY-B0500
    Alverine citrate 5560-59-8 99.71%
    Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM.
    Alverine citrate
  • HY-B1165
    Cyproheptadine hydrochloride sesquihydrate 41354-29-4 99.82%
    Cyproheptadine hydrochloride sesquihydrate is an antihistamine and is an antagonist of serotonin and histamine2.
    Cyproheptadine hydrochloride sesquihydrate
  • HY-B1477
    Clopamide 636-54-4 ≥99.0%
    Clopamide is an orally active thiazide-like diuretic agent that inhibits the sodium-coupled chloride cotransporter SLC12A3. Clopamide has the potential for hypertension and cardiac failure research.
    Clopamide
  • HY-B1745
    Pyridoxylamine 85-87-0 99.91%
    Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.
    Pyridoxylamine
  • HY-D1445
    LysoSensor PDMPO 98.77%
    PDMPO, a lysosome pH indicator, is an excellent fluorescent acidotropic reagent for fluorescence imaging. PDMPO is a potent tool with which to study acidic organelles of live cells. PDMPO exhibits pH-dependent dual-excitation and dual-emission spectral peaks. PDMPO produces a blue fluorescence in weakly acidic organelles and shifts to yellow in more acidic lysosomes (Abs=329 nm; Em=440 nm).
    LysoSensor PDMPO
  • HY-N0059
    D-arabinose 10323-20-3 ≥99.0%
    D-arabinose is an endogenous metabolite.
    D-arabinose
  • HY-N1461
    Dihydrodaidzein 17238-05-0 99.85%
    Dihydrodaidzein is one of the most prominent dietary phytoestrogens.
    Dihydrodaidzein
  • HY-N2381
    Menthone 10458-14-7 ≥98.0%
    Menthone, an orally active monoterpene that can be isolated from plants and Mentha oil with antibacterial, antitumor, antioxidation, and antivirus properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni infection and rheumatoid arthritis.
    Menthone
  • HY-N3405
    Lariciresinol 27003-73-2 ≥98.0%
    Lariciresinol is an orally active ingredient. Lariciresinol can be isolated from Arabidopsis thaliana. Lariciresinol inhibits α-glucosidase activity (IC50 of 6.97 μM; Ki of 0.046 μM). Lariciresinol dereases Bcl-2, upregulates Bax and induces Apoptosis. Lariciresinol regulates TGF-β and NF-κB pathways. Lariciresinol has antitumor activity against liver cancer, gastric cancer, and breast cancer. Lariciresinol shows antifungal activity and anti-diabetic activity.
    Lariciresinol
  • HY-N3686
    D-Arabitol 488-82-4 ≥98.0%
    D-Arabitol is a polyol and its accumulation may cause a neurotoxic effect in human.
    D-Arabitol
  • HY-N3962
    Glycyrrhisoflavone 116709-70-7 ≥99.0%
    Glycyrrhisoflavone, an active prenylflavonoid, inhibits α-glucosidase.
    Glycyrrhisoflavone
  • HY-N6858
    4-Hydroxyisoleucine 781658-23-9 ≥98.0%
    4-Hydroxyisoleucine is an orally active amino acid that can be isolated from fenugreek seeds. 4-Hydroxyisoleucine displays insulinotropic and antidiabetic properties.
    4-Hydroxyisoleucine
Cat. No. Product Name / Synonyms Application Reactivity